BRANDplates^® Insert System for 3D Cell Culture

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The NEW BRANDplates® Insert System is an innovative microplate system for cell culture applications such as co-culture, migration/invasion assays, andin vitropreparation of 3D tissue models.

For the Insert System BRAND offers a standard 24-well plate and a special 6-well model, each of them available with the surfaces pureGrade™(untreated) or cellGrade™ plus(hydrophilic cell culture). Each plate system can be outfitted with a set of inserts.

The plates are manufactured according to the requirements in ANSI/SLAS Standards 1 and 4, and are supplied with lids with condensation rings. All plates have guide ridges for perfect insert fit and specially designed feeding ports for easy media changes and use with robotic equipment.

Standard 24-Well Plate
The plate includes 24 individually fillable wells that can be fitted with strips of 4 inserts and/or individual inserts. Each well has a guide grooves to center and hold the insert in place. This prevents the individual inserts from rotating - the feed ports on the wells remain open.

Specialized 6-Well Plate
The plate has 6 rows of 4 wells connected as one large, elongated well. This well is fitted with a strip of 4 inserts so that all 4 of the inserts in the strip can be supplied with medium at the same time. Particularly well suited to the use of insert strips with inlet channels.

Insert Strips, Membranes, and Pore Sizes

Smooth-walled Inserts or Inserts with Inlet Opening System (IOS) are available with two membranes (PC or PET) that are treated with a cellGrade™ plus in 4 pore sizes.

Through the many possible combinations of the Insert System you can respond flexibly to the different experimental needs and create perfect culture conditions.

Pore size              Areas of application

0.4 µm                  Co-culture, transport studies, secretion studies, cell polarity studies, etc.
1 µm                     Co-culture, transport studies, secretion studies, etc.
3 µm                     Migration/invasion studies, chemotaxis studies, metastasis experiments, etc.
8 µm                     Migration/invasion studies, chemotaxis studies, metastasis experiments, etc.
See also the construction of full-thickness skin models by the Fraunhofer IGB
(www.tissue-factory.com)